Transition Period, Negative Energy Balance and Oxidative Stress
DOI:
https://doi.org/10.5281/zenodo.15095608Keywords:
Cow, Nutritional Diseases, OxidationAbstract
The transition period, lasting three weeks before and three weeks following parturition, is critical for high-yielding dairy cows. Hormonal and metabolic changes occur during this period. The energy requirements increase significantly with the onset of lactation. However, if dry matter intake is insufficient, the energy need cannot be met. In this case, the cow attempts to compensate for this by mobilizing its body fat reserves. This leads to the production of free radicals and oxidative stress. Nutritional diseases such as abomasum displacement, hypocalcemia, ketosis, fatty liver, mastitis, metritis, retained placenta, acidosis, and laminitis are particularly common during the transition period in high-yielding cattle. They are all interrelated, and oxidative stress often accompanies or exacerbates many of these diseases. Furthermore, the emergence of one of these diseases triggers the development of others.
References
Ametaj, B. N., Bradford, B. J., Bobe, G., Nafikov, R. A., Lu, Y., Young, J. W., & Beitz, D. C. (2005). Strong relationships between mediators of the acute phase response and fatty liver in dairy cows. Canadian Journal of Animal Science, 85(2), 165-175.
Beran, J., Stádník, L., Ducháček, J., Okrouhlá, M., Doležalová, M., Kadlecová, V., & Ptáček, M. (2013). Relationships among the cervical mucus urea and acetone, accuracy of insemination timing, and sperm survival in Holstein cows. Animal Reproduction Science, 142(1-2), 28-34.
Bezdíček, J., Nesvadbová, A., Ducháček, J., Sekaninová, J., Stádník, L., & Janků, M. (2024). Changes in the oxidative-biochemical status in dairy cows during the transition period affecting reproductive and health parameters. Review. Czech Journal of Animal Science, 69(9), 345-355.
Büyükoğlu, T., & Aslan, N. (2018). Oksidatif stres ve geçiş dönemi süt sığırlarında oksidatif stresin etkileri. Türkiye Klinikleri Veteriner Bilimleri Dergisi, 9(2), 33-41.
Catalani, E., Amadori, M., Vitali, A., Bernabucci, U., Nardone, A., & Lacetera, N. (2010). The Hsp72 response in peri-parturient dairy cows: relationships with metabolic and immunological parameters. Cell Stress and Chaperones, 15(6), 781-790.
Cattaneo, L., Lopreiato, V., Piccioli-Cappelli, F., Trevisi, E., & Minuti, A. (2021). Plasma albumin-to-globulin ratio before dry-off as a possible index of inflammatory status and performance in the subsequent lactation in dairy cows. Journal of dairy science, 104(7), 8228-8242.
Collet, S. G., Sousa, R. D. S., Ortolani, E. L., Thaler Neto, A., Carpeggiani, M. C., Ferronatto, T. C., ... & Leal, M. L. D. R. (2019). Effect of using trace minerals (copper, zinc, selenium, and manganese) and vitamins A and E on the metabolic profile of Holstein cows in the transition period. Semina: Ciencias Agrarias, 40(5), 1879-1890.
Curtis, C. R., Erb, H. N., Sniffen, C. J., Smith, R. D., Powers, P. A., Smith, M. C., ... & Pearson, E. J. (1983). Association of parturient hypocalcemia with eight periparturient disorders in Holstein cows. Journal of the American Veterinary Medical Association, 183(5), 559-561.
De Koster, J., Salavati, M., Grelet, C., Crowe, M. A., Matthews, E., O'Flaherty, R., ... & Hostens, M. (2019). Prediction of metabolic clusters in early-lactation dairy cows using models based on milk biomarkers. Journal of dairy science, 102(3), 2631-2644.
Ducháček, J., Stádník, L., Ptáček, M., Beran, J., Okrouhlá, M., & Gašparík, M. (2020). Negative energy balance influences nutritional quality of milk from Czech Fleckvieh cows due changes in proportion of fatty acids. Animals, 10(4), 563.
El-Deeb, W. M., & El-Bahr, S. M. (2017). Biomarkeri ketoze u mliječnih krava u postpartalnom razdoblju: proteini akutne faze i proupalni citokini. Veterinarski arhiv, 87(4), 431-440.
Folnožić, I., Turk, R., Đuričić, D., Vince, S., Pleadin, J., Flegar–Meštrić, Z., ... & Samardžija, M. (2015). Influence of body condition on serum metabolic indicators of lipid mobilization and oxidative stress in dairy cows during the transition period. Reproduction in domestic animals, 50(6), 910-917.
Hayırlı, A., Kaynar, Ö., & Serbester, U. (2012). Hepatik Lipidoz ve Ketozis. Turkiye Klinikleri Journal of Veterinary Sciences, 3(1), 38-69.
Hayırlı, A., Doğan, V., Kaynar, Ö., Cengiz, M., & Ballı, B. (2016). Sütçü Sığırlarda Peripartum Prognostik ve Diagnostik Markerların Değerlendirilmesi. Turkiye Klinikleri Veterinary Sciences-Obstetrics and Gynecology-Special Topics, 2(3), 63-80.
Janovick, N. A., Trevisi, E., Bertoni, G., Dann, H. M., & Drackley, J. K. (2023). Prepartum plane of energy intake affects serum biomarkers for inflammation and liver function during the periparturient period. Journal of Dairy Science, 106(1), 168-186.
Karimi, N., Seifi, H. A., & Heydarpour, M. (2021). Assessment of some inflammatory cytokines and immunologic factors in dairy cows with subclinical ketosis. Iranian Journal of Veterinary Science and Technology, 13(2), 29-36.
Koca, N., & Karadeniz, F. (2003). Serbest radikal oluşum mekanizmaları ve vücuttaki antioksidan savunma sistemleri. Gıda Mühendisliği Dergisi, 16(2), 36-37.
Lean, I. J., Van Saun, R., & DeGaris, P. J. (2013). Mineral and antioxidant management of transition dairy cows. Veterinary Clinics: Food Animal Practice, 29(2), 367-386.
LeBlanc, S. J., Herdt, T. H., Seymour, W. M., Duffield, T. F., & Leslie, K. E. (2004). Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease. Journal of dairy science, 87(3), 609-619.
Ma, J., Kok, A., Burgers, E. E. A., Bruckmaier, R. M., Goselink, R. M. A., Gross, J. J., Kemp, B., Lam, T. J. G. M., Minuti, A., Saccenti, E., Trevisi, E., Vossebeld, F., & Van Knegsel, A. T. M. (2024). Time profiles of energy balance in dairy cows in association with metabolic status, inflammatory status, and disease. Journal of dairy science, S0022-0302(24)00977-9. Advance online publication. https://doi.org/10.3168/jds.2024-24680
Mezzetti, M., Minuti, A., Piccioli-Cappelli, F., Amadori, M., Bionaz, M., & Trevisi, E. (2019). The role of altered immune function during the dry period in promoting the development of subclinical ketosis in early lactation. Journal of dairy science, 102(10), 9241-9258.
Petrovic, M.Z., Cincovic, M., Staric, J., Djokovic, R., Belic, B., Radinovic, M., Majkic, M., Ilic, Z.Z.(2022). The correlation between extracellular heat shock protein 70 and lipid metabolism in a ruminant model. Metabolites. Dec 27;12(1):19.
Píšťková, K., Kazatelová, Z., Procházková, H., Danielová, L., Illek, J., (2018). Antioxidant status and concentration levels ofmalondialdehyde (MDA) in dairy cows during periparturientperiod. Hungar. Vet. J. 140, Suppl. 1, 312-319.
Putman, A. K., Brown, J. L., Gandy, J. C., Wisnieski, L., & Sordillo, L. M. (2018). Changes in biomarkers of nutrient metabolism, inflammation, and oxidative stress in dairy cows during the transition into the early dry period. Journal of dairy science, 101(10), 9350-9359.
Rutherford, A. J., Oikonomou, G., & Smith, R. F. (2016). The effect of subclinical ketosis on activity at estrus and reproductive performance in dairy cattle. Journal of dairy science, 99(6), 4808-4815.
Shen, T., Li, X., Loor, J. J., Zhu, Y., Du, X., Wang, X., ... & Liu, G. (2019). Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows. Journal of dairy science, 102(11), 10554-10563.
Singh, R. (2015). Prediction and management of metabolic diseases in dairy cows and buffaloes.
Song, Y., Li, X., Li, Y., Li, N., Shi, X., Ding, H., ... & Wang, Z. (2014). Non-esterified fatty acids activate the ROS–p38–p53/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro. Apoptosis, 19, 984-997.
Sordillo, L. M. (2013). Selenium‐dependent regulation of oxidative stress and immunity in periparturient dairy cattle. Veterinary medicine international, 2013(1), 154045.
Stádník, L., Bezdíček, J., Makarevich, A., Kubovičová, E., Louda, F., Fellnerová, I., ... & Holásek, R. (2017). Ovarian activity and embryo yield in relation to the postpartum period in superovulated dairy cows. Acta Veterinaria BRNO, 86(1), 51-57.
Sun, X., Tang, Y., Jiang, C., Luo, S., Jia, H., Xu, Q., ... & Xu, C. (2021). Oxidative stress, NF-κB signaling, NLRP3 inflammasome, and caspase apoptotic pathways are activated in mammary gland of ketotic Holstein cows. Journal of Dairy Science, 104(1), 849-861.
Tremblay, M., Kammer, M., Lange, H., Plattner, S., Baumgartner, C., Stegeman, J. A., ... & Döpfer, D. (2018). Identifying poor metabolic adaptation during early lactation in dairy cows using cluster analysis. Journal of dairy science, 101(8), 7311-7321.
Vanholder, T., Leroy, J. L. M. R., Van Soom, A., Opsomer, G., Maes, D., Coryn, M., & de Kruif, A. (2005). Effect of non-esterified fatty acids on bovine granulosa cell steroidogenesis and proliferation in vitro. Animal reproduction science, 87(1-2), 33-44.
Vossebeld, F., van Knegsel, A. T. M., & Saccenti, E. (2022). Phenotyping metabolic status of dairy cows using clustering of time profiles of energy balance peripartum. Journal of Dairy Science, 105(5), 4565-4580.
Zahrazadeh, M., Riasi, A., Farhangfar, H., & Mahyari, S. A. (2018). Effects of close-up body condition score and selenium-vitamin E injection on lactation performance, blood metabolites, and oxidative status in high-producing dairy cows. Journal of dairy science, 101(11), 10495-10504.
Zarrin, M., Wellnitz, O., van Dorland, H. A., & Bruckmaier, R. M. (2014a). Induced hyperketonemia affects the mammary immune response during lipopolysaccharide challenge in dairy cows. Journal of dairy science, 97(1), 330-339.
Zarrin, M., Wellnitz, O., van Dorland, H. A., Gross, J. J., & Bruckmaier, R. M. (2014b). Hyperketonemia during lipopolysaccharide-induced mastitis affects systemic and local intramammary metabolism in dairy cows. Journal of Dairy Science, 97(6), 3531-3541.
Zhang, G., & Ametaj, B. N. (2020). Ketosis an old story under a new approach. Dairy, 1(1), 5.
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