VIBURNUM OPULUS VE EQUISETUM ARVENSE EKSTRAKTI TİCARİ FORMÜLASYONLARININ ANTİ-SİTOTOKSİK VE ANTİ-GENOTOKSİK AÇIDAN DEĞERLENDİRİLMESİ

Nergis KAYA

doi:10.46291/ICONTECHvol6iss1pp26-32

Authors

Nergis KAYA Canakkale Onsekiz Mart University

DOI:

https://doi.org/10.46291/ICONTECHvol6iss1pp26-32

Keywords:

Gilaburu, Kırkkilit, sitotoksisite, genotoksisite

Abstract

The effects of commercial formulations of Viburnum opulus and Equisetum arvense extract on anti-cytotoxicity and anti-genotoxicity were evaluated at the root tip of Allium cepa L. Distilled water, DMSO, ethyl methane sulfonate (EMS), 5% and 10% doses of V. opulus and E. arvense extracts were applied for 24 and 48 hours. Cytotoxicity and genotoxicity were evaluated by calculating %mitotic index and %chromosomal aberration index, respectively. When the 24h and 48h application of V. opulus and E. arvense extracts were compared with distilled water and DMSO applications; It was determined that these extracts increased the mitotic index and decreased the chromosomal aberration index. It was found that the mitotic index increased and the chromosomal aberration index decreased depending on the increase in the extract dose for 24h and 48h except for V. opulus. Chromosomal aberrations such as C-mitosis, polar shifting, and laggard chromosome were observed in A. cepa root tips meristematic cells by microscope. As a result of this research, it can be stated that commercial formulations of V. opulus and E. arvense extracts are anti-cytotoxic and anti-genotoxic in A. cepa root tip cells when compared with distilled water, DMSO and EMS groups.

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