CLPG Gene Mutation: Molecular Mechanisms, Genetic Effects, and Applications in Animal Husbandry

Özet

Feed costs and carcass yields significantly influence the profitability and sustainability of sheep production. Therefore, the selection of animals with superior feed efficiency and high-quality meat production is essential. Genetic factors play a pivotal role in animal development and in determining phenotypic characteristics. Recent advances in genetic research have highlighted the substantial impact of various gene mutations on both physiological and morphological traits. Among these, the Callipyge (CLPG) gene mutation has garnered attention due to its association with muscle hypertrophy, demonstrating a distinctive genetic mechanism and pronounced phenotypic effects. The CLPG mutation promotes enhanced muscle development in sheep, particularly in the pelvic and lumbar regions, and is considered economically valuable. This trait is inherited through a unique epigenetic mechanism known as “polar overdominance.” This article explores the molecular basis of the CLPG mutation, its physiological implications, and its potential applications in animal husbandry. Furthermore, the integration of this mutation into genetic selection programs, its influence on meat quality, and the ethical considerations surrounding its use are critically examined.