Comparative Evaluation of the Phenolic Profiles of Salvia hydrangea DC. ex Benth. (Sage) Samples Collected from Different Locations in Iğdır Province by HPLC–DAD and Their Potential Applications in the Cosmetic and Health Sectors

Kenan  AKBAŞ; Mahmut YILDIZTEKİN; Musa  KARADAĞ; Beşir DAĞ; Mehmet Fırat  BARAN

doi:10.5281/zenodo.21209194

Authors

Kenan AKBAŞ Muğla Sıtkı Koçman University https://orcid.org/0000-0002-0198-4668
Mahmut YILDIZTEKİN Muğla Sıtkı Koçman University https://orcid.org/0000-0002-0206-0117
Musa KARADAĞ Iğdır University https://orcid.org/0000-0003-2498-3403
Beşir DAĞ Batman University https://orcid.org/0000-0002-5208-3552
Mehmet Fırat BARAN Batman University https://orcid.org/0000-0001-8133-6670

DOI:

https://doi.org/10.5281/zenodo.21209194

Keywords:

Salvia hydrangea DC., ex Benth., HPLC–DAD, Phenolic compounds, DNA interaction, Molecular docking, Rosmarinic acid, Antioxidant activity, Plant extracts

Abstract

Salvia ortanca DC. eski Benth. (adaçayı), zengin fenolik bileşimi ve iyi belgelenmiş antioksidan, antimikrobiyal ve antiinflamatuar özellikleri ile verilen önemli bir tedavi ve aromatik bitkidir. Bu etkili, Türkiye'nin Iğdır ilinin Karaçomak ve Asma köylerinden Salvia hydrangea DC. eski Benth. Örneklerin fenolik profilleri, diyot dizili dedektörlü, yüksek performanslı sıvı kromatografisi (HPLC-DAD) belirlendi. Örnekler arasındaki kimyasal farklılıklar kemometrik analizlerle değerlendirilmiş ve ana fenolik resimlerin DNA ile iletişimleri bağlantıları kenetleme analizi ayrıntılı olarak araştırılmıştır. Sonuçlar, her iki baskın fenolik asitin rosmarinik asit örneği olduğunu, ayrıca klorojenik asit, kateşin, kuersetin, değişim, o -kumarik asit ve naringinin de tanımlandığını ortaya çıkardı. Karaçomak örneği, Asma örneğine göre anlamlı derecede daha yüksek toplam fenolik içeriği ve rosmarinik asitin saklandığı belirtilir. Kemometrik analizler, örnek fenolik profillerine göre başarılı bir şekilde sınıflandırılarak, başlangıç kökeninin kimyasal bileşimleri üzerinde açık güç çözümleri. Moleküler kenetlenme analizi, değişim ve rosmarinik asitlerin DNA'ya karşı sırasıyla -8,1 ve -7,8 kcal/mol bağlanma serbest enerjileri sergilendiği bağlantılardır. Krizin, öncelikle π–π istifleme izinleriyle küçük oluk aktarım yoluyla DNA ile geçişe girerken, rosmarinik asit çoklu hava bağları ve van der Waals izinleriyle stabilize edilmiş güçlü bir bağlantı oranları sergilendi. Bu hastalığın kökeninin Salvia hydrangea DC. ex Benth.'in fenolik performansıi analiz eden bir faktör olduğunu göstermekte ve fenolik madde açısından zengin adaçayı özlerinin kozmetik, dermokozmetik ve sağlık uygulamaları için umut destekli doğal biyoaktif kaynaklar olduğunu vurgulamaktadır.

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Comparative Evaluation of the Phenolic Profiles of Salvia hydrangea DC. ex Benth. (Sage) Samples Collected from Different Locations in Iğdır Province by HPLC–DAD and Their Potential Applications in the Cosmetic and Health Sectors

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